I've noted the reception to the SE50 has been lukewarm here. I understand its a"Student Edition". However I wanted an EL34 combo that was reasonably priced. So I bought one. One great feature is the bias jacks on the back panel. So I check the bias and the setting is 30, which is below the suggested setting of 37 in the manual and less than I would set EL34s at. I know many amp manufacturers set the bias on the cold side as a safer option regarding tube failure and sound.
So I set the tubes on 37 and this amp came alive. It's a beast. I use the clean channel with the gain at about 2 o'clock and the master volume at about 11 o'clock. I agree with other comments about the lead channel sounding fizzy on higher gain settings. So my best use of this amp is with the clean channel on higher gain or the lead channel on lower gain setting.
Now I put in a set of NOS 6CA7s and it's a whole 'nother level of special.
My reference is my 1969 small box Marshall 50 watt head and it compares favorably tone wise, in a package I can easily tote to gigs.
However, it is a very sensitive amp and will respond deftly to nuances of left hand technique and pick attack, so no hiding sloppy playing.
PRS has brought a boutique quality amp to the masses here. I'm not happy about the power tube sockets on the board and not the chassis. But I believe reverse engineering the tone worked.